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“Introduction Klotho has been investigated as an anti-aging protein that is predominantly expressed in the distal convoluted tubules in the kidney and in the choroid plexus of the brain, although the expression level of Klotho is higher in the kidneys . The klotho gene encodes a single-pass transmembrane protein with a long extracellular domain and a short cytoplasmic tail that functions as a co-receptor for fibroblast growth factor-23 (FGF23) and plays a role in phosphate metabolism .