Science 302:1575–1577PubMed 49. Verdijk LB, Koopman R, Schaart G, Meijer K, Savelberg HH, van Loon LJ (2007) Satellite cell content is specifically reduced in type II skeletal muscle fibers in the elderly. Am J Physiol Endocrinol Metab 292:E151–157PubMed 50. Dreyer HC, Blanco CE, Sattler FR, Schroeder ET, Wiswell RA (2006) Satellite cell numbers in young and older men 24 hours after eccentric exercise. Muscle Nerve 33:242–253PubMed 51. Gallegly JC, Turesky NA, Strotman BA, Gurley CM, Peterson CA, Dupont-Versteegden

EE (2004) Satellite cell regulation of muscle mass is altered at old age. J Appl Physiol 97:1082–1090PubMed 52. Bigot A, Jacquemin V, Debacq-Chainiaux F, Butler-Browne GS, Toussaint O, Furling this website D, Mouly V (2008) Replicative aging down-regulates the myogenic regulatory factors in human myoblasts. Biol Cell 100:189–199PubMed 53. McCroskery S, Thomas M, Maxwell L, Sharma M, Kambadur R (2003) Myostatin negatively regulates satellite

cell activation and self-renewal. J Cell Biol 162:1135–1147PubMed 54. Kawada S, Tachi C, Ishii N (2001) Content and localization of myostatin in mouse skeletal muscles during aging, mechanical find more unloading and reloading. J Muscle Res Cell Motil 22:627–633PubMed 55. Baumann AP, Ibebunjo C, Grasser WA, Paralkar VM (2003) Myostatin expression in age and denervation-induced skeletal muscle atrophy. J Musculoskelet Neuronal Interact 3:8–16PubMed 56. Welle S (2002) Cellular and molecular basis of age-related sarcopenia. Can J Appl Physiol 27:19–41PubMed 57. Raue U, Slivka D, Jemiolo B, Hollon C, Trappe S (2006) Myogenic gene expression at rest and after a bout of resistance exercise in young (18–30 yr) and old (80–89 yr) women. J

Appl Diflunisal Physiol 101:53–59PubMed 58. Shadwick RE (1990) Elastic energy storage in tendons: mechanical differences related to function and age. J Appl Physiol 68:1033–1040PubMed 59. Nakagawa Y, Hayashi K, Yamamoto N, Nagashima K (1996) Age-related changes in biomechanical properties of the Achilles tendon in rabbits. Eur J Appl Physiol Occup Physiol 73:7–10PubMed 60. Blevins FT, Hecker AT, Bigler GT, Boland AL, Hayes WC (1994) The effects of donor age and strain rate on the biomechanical properties of bone–patellar tendon–bone allografts. Am J Sports Med 22:328–VX-770 333PubMed 61. Flahiff CM, Brooks AT, Hollis JM, Vander Schilden JL, Nicholas RW (1995) Biomechanical analysis of patellar tendon allografts as a function of donor age. Am J Sports Med 23:354–358PubMed 62. Narici MV, Maffulli N, Maganaris CN (2008) Ageing of human muscles and tendons. Disabil Rehabil 30:1548–1554PubMed 63. Maganaris CN, Paul JP (1999) In vivo human tendon mechanical properties. J Physiol 521(Pt 1):307–313PubMed 64. Reeves ND, Narici MV, Maganaris CN (2003) Strength training alters the viscoelastic properties of tendons in elderly humans. Muscle Nerve 28:74–81PubMed 65. Narici MV, Maganaris CN (2006) Adaptability of elderly human muscles and tendons to increased loading. J Anat 208:433–443PubMed 66.