2% had ejection fraction >40%.) Our findings are consistent

with those of another prospective study on 325 patients who had undergone coronary angiography. The researchers aimed to find the optimal strategy for administering Navitoclax nmr heparin during coronary angiography; however, they did not find a significant difference between the two case (receiving heparin) and control groups with respect to ischemic, hemorrhagic, and Inhibitors,research,lifescience,medical vascular complications.5 Zibaeenezhad et al.13 reported no significant increase in ischemic complications after omission of heparin infusion in patients undergoing coronary intervention. Nevertheless, they reported that heparin would increase the occurrence of bleeding and vascular injury. Datta et al.16 reported no periprocedural ischemic complications during coronary angiography, which was performed without heparin, and they emphasized Inhibitors,research,lifescience,medical that coronary angiography through the femoral artery could be performed without heparin. A meta-analysis conducted by Johanne Silvain et al.14 reported that during percutaneous coronary intervention, Enoxaparin seemed to be superior to unfractionated heparin in reducing all-cause mortality as well as ischemic and bleeding complications. Whereas the

results Inhibitors,research,lifescience,medical of some studies chime in with the results of the present study, there are studies that have suggested further investigation to determine the optimal strategy for heparin administration.4,6 Miller6 investigated the current patterns of the use of heparin in angiography and suggested that further studies be done on the administration of heparin as an anticoagulant. Some studies have reported increased risk Inhibitors,research,lifescience,medical of hematoma post administration of heparin. A study which was conducted on 322 patients to assess hematoma and its risk factors reported that the use of anticoagulant agents might increase the risk of the occurrence of hematoma.17 On the other hand, previous case reports have shown the increased risk of pituitary apoplexy and perirenal hematoma following coronary angiography in patients who had used anticoagulant agents.18,19 According to some textbooks, there

Inhibitors,research,lifescience,medical is no absolute indication for administering routine intravenous heparin during coronary angiography crotamiton through the femoral approach. However, in the case of patients at high risk of thromboembolic complications (for example, in conditions such as severe aortic stenosis, severe peripheral vascular disease, and long use of the guide wire in the peripheral blood flow), heparin administration is advised. Absolute indication exists in the radial and brachial approaches.20 Other textbooks have generally suggested the intravenous administration of 2-3 thousands units of heparin upon catheterization, without defining any indications.2 An important limitation of this study was the fact that we did not record the exact duration of the procedure. Moreover, we merely excluded procedures which lasted more than 30 minutes.