23–25 The researcher who performed the interview was blinded to the presence or not of CD. Interviews were specifically addressed to determine the incidence and characteristics of falls based on a previously described questionnaire.19 Patients’ medical records were revised to check and complete the information given by patients and relatives. To define falls, we used the World Health Organization definition as follows: “A fall is an event which results in a person coming to rest inadvertently Tyrosine Kinase Inhibitor Library cell line on the ground or floor or other lower level.”26 The incidence of falls and the mean number of falls per patient were determined. Severity of injuries and the healthcare needed for falls

were also recorded. Fall injuries were classified as contusion, wound, or fracture.12, 27 Healthcare needed was classified as primary care, emergency learn more room care, or hospitalization.12, 28 We also recorded the duration of hospitalization resulting from falls and whether or not patients presented with decompensation of cirrhosis

during this admission. Falls were analyzed by comparing patients with cirrhosis and with CD to those without CD, and we evaluated the characteristics of patients according to whether or not they presented with falls during the follow-up. The last 31 patients included in the study completed the Timed Up-and-Go Test (TUG) and were evaluated for the presence of orthostatic hypotension immediately after the PHES and CFF tests were performed. The TUG can be used to assess the risk of falls.29 The test determines the time needed to get up from a chair, walk 3 meters, turn around, and walk back to sit down again without support and in a standardized environment.29 To assess orthostatic hypotension, blood pressure was measured twice before this test: first with the patient seated and then after standing up. Orthostatic hypotension was defined as a decrease in systolic blood pressure of at least 20 mmHg or a decrease in diastolic blood pressure of at

least 10 mmHg within 3 minutes of standing.30 Patients with CD were compared with those without CD and patients with falls were compared with those without falls, using Fisher’s exact test for categorical variables and the medchemexpress Student’s t test and Mann-Whitney’s U test for quantitative variables. Parameters that reached statistical significance in the univariate analysis were included in a multivariate analysis by logistic regression to identify the independent factors associated with falls. We used a forward stepwise selection procedure with Wald’s test to determine the best model. The predictive ability of the resulting model was evaluated using the area under the receiver operating characteristics curve (AUROC). Probability curves were obtained by the Kaplan-Meier’s method and were compared using the log-rank test. Correlations were assessed by Spearman’s test. Results are presented as mean ± SD or frequencies. Calculations were performed with the SPSS Statistical Package (version 18.