Among men, the age-standardized rates were 17.4 (95 % CI 16.1–18.7) for manual workers and 9.8 PU-H71 (95 % CI 8.8–10.8) for non-manual workers, corresponding to a 1.8-fold excess in the former. Age-standardized rates among women AZD9291 were 11.1 (95 % CI 9.8–12.3) for manual workers, 9.5 (95 % CI 8.3–10.8) for housewives and 5.7 (95 % CI 4.8–6.6) for non-manual workers. Thus, female manual workers had a 1.9-fold FK866 in vitro higher rate of surgically treated idiopathic RRD than their non-manual counterparts, and housewives experienced a

1.7-fold excess. Figure 1 shows age-specific rates for men and women, according to broad occupational categories (for numbers of cases, see Table 2). Highly significant age-related trends in incidence rates were apparent in all the occupational categories under study: RRs for each 5-year increase in age class were 1.46 (95 % CI 1.41–1.52) for male manual workers, 1.38 (95 % CI 1.31–1.46) for male non-manual workers, 1.36 (95 % CI 1.29–1.45) for female manual Rebamipide workers, 1.38 (95 % CI 1.27–1.50) for female non-manual workers, and 1.22 (95 % CI, 1.15–1.29) for housewives (all P < 0.001 in the score test for trend). Fig. 1 Age-specific incidence rates of surgically treated idiopathic RRD by broad occupational category among men (a) and women (b) in Tuscany Table 2 Age- and sex-specific rates (per 100,000 person-years) of surgically treated idiopathic RRD according to broad occupational category in Tuscany Age (years) Men Women Manual workers Non-manual workers Manual workers

Non-manual workers Full-time housewives n/N Rate 95 % CI n/N Rate 95 % CI n/N Rate 95 % CI n/N Rate 95 % CI n/N Rate 95 % CI 25–29 28/805,688 3.5 2.4–5.0 11/436,436 2.5 1.4–4.6 20/484,679 4.1 2.7–6.4 12/514,280 2.3 1.3–4.1 9/133,094 6.8 3.5–13.0 30–34 58/970,671 6.0 4.6–7.7 25/578,617 4.3 2.9–6.4 28/555,594 5.0 3.5–7.3 13/639,847 2.0 1.2–3.5 17/252,486 6.7 4.2–10.8 35–39 95/931,879 10.2 8.3–12.5 44/703,261 6.3 4.7–8.4 33/528,866 6.2 4.4–8.8 20/689,884 2.9 1.9–4.5 19/353,301 5.4 3.4–8.4 40–44 120/799,669 15.0 12.5–17.9 56/653,172 8.6 6.6–11.1 45/468,533 9.6 7.2–12.9 33/604,942 5.5 3.9–7.7 36/365,820 9.8 7.1–13.6 45–49 139/676,741 20.5 17.4–24.3 62/653,887 9.5 7.4–12.2 50/404,131 12.4 9.4–16.3 39/547,911 7.1 5.2–9.7 38/415,168 9.2 6.7–12.6 50–54 168/688,220 24.4 21.0–28.4 81/597,584 13.6 10.9–16.9 71/430,937 16.5 13.1–20.8 38/410,345 9.3 6.7–12.