Benign lesions/trauma of the pancreatic neck and proximal body pose an interesting surgical challenge. Central Pancreatectomy is an operation

that allows resection of benign tumours located in the pancreatic isthmus that are not suitable for enucleation. Methods: Between 2006 and 2011, 16 parenchymal sparing conservative pancreatectomies were carried out. There were 6 women and 10 men with a mean age of 35.7 years. In 8 patients who underwent central pancreatectomy, the cephalic pancreatic stump is oversewn and the distal stump is anastomosed end–to–end with a Roux-en-Y jejunal loop see more in two and with the stomach in six patients. The indications for Central pancreatectomy were: non-functional islet cell tumours in two patients, traumatic pancreatic neck transection in two and one each for

insulinoma, solid pseudopapillary tumour, splenic artery pseudoaneurysm and pseudocyst. The indication for Pancreatic head coring (Frey’s procedure) was chronic pancreatitis with benign head mass in 7 GPCR & G Protein inhibitor patients and one underwent spleen preserving distal pancreatectomy for insulinoma in pancreatic tail. Pancreatic exocrine function was evaluated by a questionnaire method. Endocrine function was evaluated by blood glucose level. Results: Morbidity rate was 37.5% with no mortality. Mean postoperative hospital stay was 10.5 days. Neither of the patients developed pancreatic fistula nor required reoperations or interventional radiological procedures. At a mean follow up of

26.4 months, no patient had evidence of endocrine or exocrine pancreatic insufficiency, all the patients were alive and well without clinical and imaging evidence of disease recurrence. Conclusion: When technically feasible, Central Pancreatectomy is a safe, conservative pancreatectomy for non-enucleable benign pancreatic pathology confined to pancreatic isthmus that allows for cure of the disease without loss of substantial amount of normal pancreatic parenchyma with preservation of exocrine/endocrine function and without interruption of pancreatico-biliary-enteric continuity appears to have long-term functional Dichloromethane dehalogenase advantages with good quality of life. Central pancreatectomy with pancreaticogastrostomy is also a safe conservative surgical strategy worthy of consideration as an alternative to distal pancreatectomy in the setting of isolated traumatic pancreatic neck transection. Key Word(s): 1. central; 2. segmental; 3. pancreatectomy; 4. Nonstandard; Presenting Author: BING-RONG LIU LIU Additional Authors: JI-TAO SONG SONG, LING-JIAN KONG KONG Corresponding Author: BING-RONG LIU LIU Affiliations: The second affiliated hospital of Harbin medical university Objective: Peritoneal access techniques are among the most important concerns in the clinical application of natural orifice transluminal endoscopy surgery (NOTES).