beta-lapachone is a natural ortonaftoquinone extract of the Bignoniaceae plants, as Ipe Roxo (Tabebuia avellanedae Lor), tree native to Brazil, or can be synthesized from its isomer lapachol. beta-lapachone has demonstrated a range of pharmacological activities including antibacterial, antifungal, trypanocidal, antiviral and anticancer. There are no reports in the literature of a spectrophotometric method for quantification of beta-lapachone. The present research describes the development of a simple, economical, fast and accurate for the quantification of this drug. The method developed is the solubilization of beta-lapachone in absolute ethanol with subsequent

dilution in the solvent system of absolute ethyl alcohol: purified water for quantification by UV detector. The

method was validated according International Conference on harmonization (ICH Q2A /ICH Q2B) selleck see more and National Health Surveillance Agency of Brazil (RE 899/03) parameters. The results show that the validation method is robust, linear, sensitive, precise and accurate within the parameters assessed.”
“Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a cardiac disease that affects the right side of the heart and causes ventricular arrhythmias. It is considered as the most common cause of sudden cardiac death in young adults. However, risk and optimal management of ARVC during pregnancy and delivery remain unclear due to the small number of reported cases. Here we report a case of successful management selleck compound of pregnancy and delivery in a patient with ARVC, who had a history of sustained ventricular tachycardia from her previous

pregnancy.”
“The effects of the crude extract and fractions of Cayaponia podantha (Cp) on experimental inflammation models were investigated. Paw edema induced by carrageenan (Cg) and peritonitis induced by Cg, LPS, and LTB(4) were evaluated in rats treated orally with different doses of extract. Croton oil (CO) induced ear edema and the determination of MPO activity were evaluated in mice. Crude Cp extract and hexane (HF), ethyl-acetate (AF) and hidromethanol (MF) fractions were topically applied immediately after the application of the CO. Four hours after Cg injection, animals treated with crude extract (250 and 500 mg/kg) displayed significantly decreased paw edema. The Cp extract (250, 500, and 750 mg/kg) decreased vascular permeability and leukocyte migration in the peritonitis model in the 3(rd) h after induction of the inflammatory reaction. Furthermore, the 500 mg/kg dose of Cp extract also reduced LPS- and LTB(4)-induced migration. Crude extract and hexane and ethyl-acetate fractions (5.0 mg) significantly inhibited ear edema and MPO activity. Our results showed that Cp crude extract and fractions exhibited anti-inflammatory effects when they are administered orally or topically in animals.