g. [2,3]). While less common, cases of atraumatic rupture of diseased spleens are also widely reported in the literature (reviewed in [4,5]). In contrast, the phenomenon of splenic rupture in the absence of these two risk factors is not documented in emergency medicine textbooks [2,3] and we believe that it is not widely appreciated by emergency physicians. Cases of splenic Inhibitors,research,lifescience,medical rupture not fitting the description above are related by their lack of historical cues to suggest the diagnosis at presentation. This distinguishes them from other causes

of splenic rupture and highlights the importance to emergency physicians who rely a great deal on the patient history to appropriately triage patients for definitive investigation and referral. A recent systematic review of cases of atraumatic rupture of the spleen has been published [4]; however, a surprising number of the splenic rupture cases reported in this review and elsewhere represent the presenting complaint of Inhibitors,research,lifescience,medical the underlying disease process. The authors Inhibitors,research,lifescience,medical of the review do not highlight this fact which we believe to be crucial information to the practicing

clinician. Therefore, we have reviewed the literature on cases of splenic rupture for which there was not an immediately obvious cause apparent on presentation such as significant trauma (either recent or remote) or previously diagnosed disease known to affect the spleen. Methods We conducted a systematic review of English and French language papers indexed in CINAHL, Inhibitors,research,lifescience,medical PubMed and Embase using the medical subject heading (MeSH) search terms “rupture, spontaneous,”

and “splenic rupture,” (or equivalent for the different databases) combined with the textword search “undiagnosed” or “first manifestation” or “presenting” Inhibitors,research,lifescience,medical or “spontaneous.” This search strategy was combined with an additional strategy including the MeSH terms “rupture, spontaneous” and “spleen” and the free text “normal spleen;” both strategies were used together to extract relevant papers. Searches were limited to English and French language papers on human subjects published in the years Isotretinoin 1950 to 2011. We also explored multiple other textword modifiers such as “atraumatic,” “non-traumatic” and “trivial,” none of which improved the sensitivity of the search with sufficient specificity to be helpful. Searches were developed by a research librarian and one of the authors who has training in clinical epidemiology (KA). The Alvespimycin reference lists of the papers so identified were also examined for relevant additions. We elected to include papers written in other languages if an English language abstract was available that included the information necessary for our report.