Having said that, multivariate analysis employing the Cox regression model adjusted to optimal surgery did not show Aurora B as an independent prognostic element for PFS and OS . Tumors with AURKA gene amplification showed an improved PFS in comparison with these tumors with no AURKA gene amplification, although this distinction was not statistically important . Patients with AURKA gene amplification showed a decreased OS compared to those individuals without the need of AURKA gene amplification. Then again, these differences were not statistically considerable Discussion Within the present study, we have analyzed the prognostic value with the expression of Aurora kinases A and B in the DNA and protein levels in a series of ovarian carcinomas homogeneously treated having a combination of surgery and carboplatin taxane primarily based chemotherapy. The expression and mutational status of TP along with the proliferation index have been also assessed in these circumstances. In our study of ovarian cancer specimens showed expression of Aurora A protein.
There have been no statistically considerable variations in Aurora A protein expression amongst the different histopathological forms of ovarian carcinomas. These final results are in agreement with these previously reported in ovarian carcinoma that showed that expression of Aurora A protein is observed in to of those tumors . AURKA gene amplification was detected in . of ovarian carcinomas examined. Preceding IOX2 research reported that AURKA is amplified in to of ovarian cancer cell lines and primary tumors . In our series of circumstances with out gene amplification showed expression from the protein, suggesting that the expression of Aurora A is probably to become regulated not only by gene amplification but in addition by other mechanisms which include transcriptional activation and or suppression of protein degradation, since it has been demonstrated in previous research . Our study demonstrated that Aurora B is regularly expressed in ovarian carcinomas .
Aurora B is reported to type complexes with inner centromere protein and survivin, and these complexes are believed to be involved in the regulation of chromosome alignment, segregation, and cytokinesis . Within the present study, the immunohistochemical Bergenin expression of Aurora B was observed predominantly in the nucleus. Due to the fact recent studies have identified the histone H protein as a vital substrate of Aurora B kinase , nuclear localization of Aurora B seems functionally necessary. Additionally, in our circumstances, mitotic cells were constructive for Aurora B, indicating the functional involvement of Aurora B within the replication of the tumor cells. The relationship among Aurora A and p is an significant issue in carcinogenesis. It has been reported that p interacts with Aurora A and suppresses its oncogenic activity within a transactivation independent manner .