However miR-15a/16-1 down-regulated WT1 protein level not through targeting mRNAs according to the degree of complementarity with their 3′UTR. The most important thing is to shed light on the new mechanisms by which miRNA mediated their effect, which will open new avenues for miRNA action. Acknowledgements The project supported by National Natural Science Foundation of China (81000176/H0317), Zhejiang Provincial Natural Science Foundation of China (Y2090326, 2110634), Scientifical Research Foundation (Y201119952) of Zhejiang Provincial Education Department, Wang Bao-En liver fibrosis

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