METHODS
Three
Yucatan pigs underwent Cryolipolysis at 22 sites: 20 at cooling intensity factor (CIF) index 24.5 (-43.8 mW/cm2), one at CIF 24.9 (-44.7 mW/cm2), and one at CIF 25.4 (-45.6 mW/cm2). Treated areas were evaluated using photography, ultrasound, and gross and microscopic pathology. Lipids were at various times points. One additional pig underwent Cryolipolysis at various days before euthanasia.
RESULTS
The treatments resulted in a significant reduction in the superficial fat layer without damage to the overlying skin. An inflammatory response triggered by cold-induced apoptosis of adipocytes preceded the reduction see more in the fat layer. Evaluation of lipids over a 3-month period following treatment demonstrated that cholesterol and triglyceride values remained normal.
CONCLUSIONS
Cryolipolysis TPX-0005 datasheet is worthy of further study because it has been shown to significantly decrease subcutaneous fat and change body contour without causing damage to the overlying skin and surrounding structures or deleterious changes in blood lipids.
The research was funded by Zeltiq Aesthetics. Drs. Brian Zelickson, Barbara Egbert, and Robert Rhoades are paid consultants
to Zeltiq. Dr. Dieter Manstein receives royalty payments from Zeltiq related to licensing of the Cryolipolysis technology. Dr. Jessica Preciado, Dr. John Allison, and Kevin Springer are employees of Zeltiq Aesthetics.”
“The effect of olibanum administered during lactation to methimazole-treated dams on the learning of offspring was evaluated. The animals were treated for 60 days from the first day of lactation period: TH-302 purchase group 1 – tap water, group 2-0.03% methimazole and groups 3 and 4-0.03%
methimazole with 0.25% or 0.125% olibanum, respectively. The serum thyroxin level in the offspring of group 2 was significantly lower than that of group 1. However, there was no difference compared to groups 3 and 4. In a Morris water maze, the distance and time latency to reach the platform in offspring of group 2 was significantly higher than groups 1, 3 and 4. In probe trial, the time spent in target quadrant (Q(1)) by offspring of group 2 was lower than groups 1, 3 and 4. It is suggested that impaired learning and memory in the offspring of hypothyroid rats may be prevented by olibanum.”
“Statistics sits right at the heart of scientific endeavour in respiratory medicine and many other disciplines. In this introductory article, some key epidemiological concepts such as representativeness, random sampling, association and causation, and confounding are reviewed. A brief introduction to basic statistics covering topics such as frequentist methods, confidence intervals, hypothesis testing, P values and Type II error is provided.