Neurological deterioration

was found permanently in 2 patients. After a mean follow-up of 43.8 +/- 23.8 months, 15 patients (79%) became seizure free (Engel class la). Conclusions: Despite the highly eloquent location of tumors causing intractable epilepsy, our multimodal approach led to complete resection in more than two-thirds of patients with an acceptable neurological morbidity and excellent long-term seizure control. (C) 2013 S. Karger AG, Basel”
“Objective: To investigate the impact of somatic symptoms on the severity and course selleck chemical of depression in Asian patients treated for an acute episode of major depressive disorder (MDD).\n\nMethods: Three-month prospective observational study of 917 patients with MDD in psychiatric care settings of which 909 had complete main baseline data. Depression severity was assessed using the physician-rated Clinical Global Impression of Severity (CGI-S) and 17-item Hamilton Depression Rating Scale (HAMD17), and somatic symptoms were assessed using the patient-rated 28-item Somatic Symptom Inventory (SSI). Cluster analysis using baseline SSI scores grouped patients into 3 clusters with no/few, moderate or severe somatic symptoms. Four factors of SSI (pain, Z-DEVD-FMK nmr autonomic

symptoms, energy, and central nervous system) were defined and regression analyses identified which factors were associated with remission and response at 3 months follow-up.\n\nResults: Baseline depression severity (HAMD17 and CGI-S scores) was associated with more severe somatic symptoms. Remission rates differed between clusters of patients: 68.4%, 54.7% and 29.3% for no/few, moderate and severe somatic symptoms, respectively (p < 0.0001). Corresponding response rates

were 81.8%, 72.1% and 55.2% (p < 0.0001). Pain symptoms were the somatic symptoms most associated with these clinical outcomes at 3 months.\n\nLimitations: Only patients diagnosed with MDD in psychiatric care were assessed.\n\nConclusions: Somatic symptoms are frequent among Asian patients Emricasan in vitro in psychiatric care for MDD and are associated with greater clinical severity and lower response and remission rates. Among somatic symptoms, pain symptoms have the greatest prognostic value and should be taken into account when treating patients with depression. (C) 2013 Elsevier BY. All rights reserved.”
“AIM: To analyze the radiological features of multiple primary carcinoma (MPC) in the upper gastrointestinal (GI) tract, study its biological characteristics and evaluate X-ray examination in its diagnosis.\n\nMETHODS: Hypotonic double-contrast GI radiography was performed in 59 multiple primary carcinoma cases, pathologically proved by surgery or endoscopy biopsy. Radiological findings were analyzed.\n\nRESULTS: Of the 59 cases, esophageal MPC (EMPC) was seen in 24, esophageal and gastric MPC (EGMPC) in 27 and gastric MPC (GMPC) in 8. Of the 49 lesions found in 24 EMPC, hyperplastic type was seen in 23, medullary type in 9.