Objectives: To evaluate the significance of the I1307K APC gene variant selleck products as a predictive factor

for colorectal neoplasia recurrence. Methods: Methods: A prospective analysis of 383 consecutive subjects with a neoplastic finding in initial screening colonoscopy that underwent surveillance colonoscopies over a period of 10 years. All subjects were tested for the APC I1307K polymorphism. Results: Results: The overall prevalence of recurrent Colorectal carcinoma and advanced adenoma was 9.9% (38/383) and 45.4% (174/383) respectively, with a median time to diagnosis of 5 years from index colonoscopy. The APC I1307K gene variant was detected in 11.8% of subjects with recurrent lesions compared to 3.8% of subjects with normal follow-up colonoscopies (p=0.03). In a multivariate logistic regression analysis the I1307K variant was a significant risk factor for recurrent neoplasia with an OR of 3.4 (1.01-11.38, p=0.04). The variant was not significant in subjects with normal index colonoscopy who underwent follow-up exams. Conclusion: Conclusions: APC I1307K polymorphism is an important predictive factor for recurrent colorectal neoplasia after a positive index colonoscopy. Key Word(s): 1. POLYMORPHISM ; 2. PREDICTIVE FACTOR; 3. APC; Presenting Author: YAN PAN Additional Authors: NA LIU, LI XU, XIAOYIN ZHANG, XIN WANG Corresponding

Author: YAN PAN Affiliations: Xijing Hospital of Digestive Diseases Objective: To summarize and discuss the current problems in gastrointestinal tumor-associated clinical trials. Methods: A retrospective study was performed GSK126 order to summarize and discuss the problems in the gastrointestinal tumor-associated clinical trials. The issues were as follows: 1. The appropriate number of patients included in the study and statistical methods; 2. The objectives of study; 3. The ways to this website improve the compliance of patients; 4. The collection of data. Results:  The number of patients included

is crucial to the study. Inappropriate number of cases could cause either invalid data or waste of resources and prolonged trial period. Therefore, the participation of professional statisticians could help the clinicians determine the number of cases included and avoid the above problems. The goal of a study is crucial for its successful execution. The contents of a trial should be concise, otherwise it could result in ambiguous aims and scattered data collection, which influences the achievement of conclusive data. Compliance of patients is important for a successful trial. Before the trial, all patients and volunteers should be informed about their responsibilities and interest, and make sure that all patients are clear about the duration, tests and treatments of this trial. At the same time, professional psychological counseling can be introduced to ensure the progress of trials.