Online at www ​nccn ​org 36 Nygren AOH, Ameziane N, Duarte HMB,

Online at www.​nccn.​org. 36. Nygren AOH, Ameziane N, Duarte HMB, et al.: Methylation-specific MLPA (MS-MLPA): simultaneous detection of CpG methylation and copy

number changes of up to 40 sequences. Nucleic Acids Res 2005, 33:e128.PubMedCentralPubMedCrossRef 37. Dufort S, Richard MJ, Lantuejoul S, et al.: Pyrosequencing, a method approved www.selleckchem.com/products/lgk-974.html to detect the two major EGFR mutations for anti EGFR therapy in NSCLC. J Exp Clin Cancer Res 2011, 30:57.PubMedCrossRef 38. Campbell PT, Curtin K, Ulrich CM, et al.: Mismatch repair polymorphisms and risk of colon cancer, tumour microsatellite instability and interactions with lifestyle factors. Gut 2009,58(5):661–667.PubMedCentralPubMedCrossRef 39. Niessen RC, Berends MJ, Wu Y, et al.: Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary non-polyposis www.selleckchem.com/products/Belinostat.html colorectal cancer. Gut 2006,55(12):1781–1788.PubMedCrossRef 40. Wright DM, Arnold JL, Parry

B, et al.: Immunohistochemistry to detect hereditary nonpolyposis colorectal cancer in young patients: the 7-year Auckland experience. Dis Colon Rectum 2011,54(5):552–558.PubMedCrossRef 41. Ahnen DJ: The American college of gastroenterology Emily couric lecture — the adenoma – carcinoma sequence revisited: has the Era of genetic tailoring finally arrived? Am J Gastroenterol 2011, 106:190–198.PubMedCrossRef 42. Berndt SI, Platz EA, Fallin MD, et al.: Mismatch repair polymorphisms and the risk of colorectal

cancer. Int J Cancer 2007, 120:1548–1554.PubMedCrossRef 43. Bussolati G, Leonardo E: Technical pitfalls potentially affecting diagnoses in immunohistochemistry. J Clin Pathol 2008, 61:1184–1192.PubMedCrossRef 44. Hassen S, Boman BM, Ali N, et al.: Detection of DNA mismatch repair proteins in fresh human blood lymphocytes – towards a novel method for hereditary non polyposis colorectal cancer (lynch syndrome) screening. J Exp Clin Cancer Res 2011, 30:100.PubMedCrossRef Competing interests The authors declare that they have Racecadotril no competing interests. Authors’ contributions VS conceived of the study, participated in its design and coordination and performed clinical and endoscopic examination. LSM collected data, performed clinical and endoscopic examination and drafted the manuscript. AM carried out the mutational analysis, MD and BC carried out immunohistochemistry and Microsatellite instability analysis, IS performed statistical analysis and MA provided a critical revision of the manuscript. All authors read and approved the final manuscript.”
“Background Pancreatic carcinoma is the tenth most common malignant tumor, but is the fourth most common cause of cancer-related deaths worldwide [1]. Less than 20% of pancreatic carcinoma patients are suitable for surgical resection, the majority of cases of pancreatic carcinoma are diagnosed at the locally advanced or metastatic stage.

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