Overall, infection occurred more often in obese patients, with an odds ratio of 1.90 (95% confidence interval [CI], 1.46 to 2.47). Deep infection requiring surgical debridement was reported in nine studies including 5061 patients (I-2, 0%). Deep infection occurred more often in obese patients, with an odds ratio of 2.38 (95% CI, 1.28 to 4.55). Revision of the total knee arthroplasty, defined as exchange or removal of the components for any reason, was documented in eleven studies including 12,101 patients (I-2, 25%). Revision for any reason occurred more often in obese patients, with an odds ratio of 1.30 (95% CI, 1.02 to 1.67).

Conclusions:

Obesity had a negative influence on outcome after total knee arthroplasty.”
“Free-radical I BET 762 chain polymerization kinetics of vinyl acetate (VA) and acrylic acid (AA) exhibit some unusual control features. The VA radicals have a high rate of chain transfer leading to relatively sluggish propagation rates. Polymerization of AA, however, is prone to autoacceleration behavior in bulk, solution, and

precipitating media. Thus, conventional statistical copolymerization of VA and AA would result in the preferential formation of high AA content copolymer. However, when the reaction medium is chosen in such a way that the copolymer precipitates LDC000067 in vitro above the lower critical solution temperature (LCST), propagation control and even monomer sequence control are obtained. Under these Ro 61-8048 datasheet conditions, when the VA charge is much greater than AA, a tapered block copolymer (VA-t-AA) is obtained. We report a single stage polymerization process for the synthesis of such materials. The presence of VA-t-AA products is verified by emulsification,

solubility, fractionation, size exclusion chromatography, NMR, and thermal analyses. In addition, propagation control can virtually eliminate formation of bimodal MWD and random/homopolymer materials that are associated with various chain transfer mechanisms in conventional polymerization routes. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 113: 3872-3882, 2009″
“Precipitation of etoposide and adverse events associated with the co-solvents in intravenous solutions can be avoided by using liposomal etoposide (LE). The pharmacokinetics and distribution of the commercial formulation (ETPI) and LE were compared in rats. The pharmacokinetic profiles were biphasic and similar in the initial phase (C(max), Vd, and t(1/2a)). However, LE showed a 60% increase in AUC with a 35% decrease in clearance (p<0.05). This decreased clearance resulted in a 70% increase in the MRT of etoposide. The uptake of etoposide from LE was higher in macrophage-phagocytic endowed tissues indicating that LE is superior to ETPI for targeted delivery of etoposide.”
“Background: Recombinant human bone morphogenetic protein-2 (rhBMP-2) is an osteoinductive protein.