Published by Elsevier Ltd. All rights reserved.”
“A new jacaranone derivative, 2-(1,6-dihydroxy-4-oxocyclohex-2-enyl) acetic acid (1), has been isolated from the whole plants of Senecio scandens var. incisus, together with three known compounds: 2′-(p-hydroxyl-cinnamoyl)-6′-jacaranone-D-glucopyranoside
(2), 2′-caffeoyl-6′-jacaranone-D-glucopyranoside (3) and kampferol-3-rhamnoside (4). Their structures were elucidated on the basis of spectroscopic data analyses and by selleckchem comparison with the related known compounds. Cytotoxic activities of 1 against three human tumour cell lines have been evaluated by the MTT method.”
“Objective: To develop a new macroscopic scoring system which allows for an overall judgment of experimental articular cartilage repair and compare it with four existing scoring systems and high-field magnetic resonance imaging (MRI).
Methods: A new macroscopic scoring system was developed to assess the repair of cartilage defects. Cartilage repair was graded by three observers with different experience in cartilage research at 2-3 time points and compared with the protocol A of the international cartilage repair society (ICRS) cartilage repair assessment score, the Oswestry arthroscopy score, and macroscopic grading systems designed by Jung and O’Driscoll. Parameters were correlated with the two-dimensional (2D) magnetic resonance observation of
cartilage repair tissue (MOCART) score based on a 9.4 T MRI as an external learn more reference standard.
Results: All macroscopic scores exhibited high intra- and interobserver reliability and high internal correlation. MK-2206 cost The newly developed macroscopic scoring system had the highest intraobserver [0.866 <= intraclass correlation (ICC) <= 0.895] and the highest interobserver reliability (ICC = 0.905) for “”total points”". Here. Cronbach’s alpha indicated good homogeneity and functioning of the items (mean = 0.782). “”Total points”" of the 2D MOCART score correlated with all macroscopic scores (all P < 0.0001). The newly developed
macroscopic scoring system yielded the highest correlation for the MRI parameter “”defect fill”" (rho = 0.765; all P < 0.0001).
Conclusions: “”Total points”" and “”defect fill”", two clinically relevant indicators of cartilage repair, can be reliably and directly assessed by macroscopic evaluation, using either system. These data support the use of macroscopic assessment to precisely judge cartilage repair in preclinical large animal models. (C) 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.”
“Propolis, a natural product derived from plant resins collected by honeybees, has been reported to exert a wide spectrum of biological functions. This research aimed at investigating the effect of propolis on the proliferation of human leukaemia HL-60 cells and whether propolis might induce apoptosis in HL-60 cells.