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to an invasive insect pest of coffee. Proc Natl Acad Sci USA 2012, 109:4197–4202.PubMed Competing interests The authors have declared that no competing interests exist. Authors’ contributions NS carried out the experiments, performed BioNumerics analysis and drafted the manuscript. JF participated in the coordination of the study NVP-BSK805 mouse and helped to draft the manuscript. PVB conceived of the study, participated in its design and coordination, carried out experiments, performed bioinformatic analysis and drafted the manuscript. All authors read and approved the final manuscript.”
“Background In addition to its role as energy source, glucose is a powerful signaling molecule which modulates many cellular responses in eukaryotic organisms, ranging from cell cycle control and differentiation to transcriptional and translational regulation [1]. The regulatory pathways involved in such

signaling become particularly patent in simple eukaryotic organisms like budding or fission yeasts, where this sugar is the preferred carbon source for vegetative growth [2]. In the fission yeast Schizosaccharomyces pombe glucose may be fermented under aerobic conditions (Crabtree effect), and a reduction in its concentration strongly affects cell metabolism and gene expression [3]. Moreover, fission yeast cells lack Acyl CoA dehydrogenase enzymes of the glyoxylate cycle to maintain diauxic growth in the absence of glucose, and this feature limits to glycerol or gluconate their ability to grow on non-sugar carbon sources [4, 5]. Hence, as soon as glucose disappears and respiration of the fermentation products becomes impaired S. pombe undergoes a nutritional stress [3]. Evidence has accumulated to support a key role of mitogen-activated protein kinase (MAPK) signaling pathways in the response of eukaryotic cells against environmental alterations and stress conditions [6].