Recently, active research on curcumin with respect to aging and related traits in model organisms has demonstrated that curcumin and its metabolite, Selleckchem INCB28060 tetrahydrocurcumin (THC), increase mean lifespan of at least three model organisms: nematode roundworm, fruit fly Drosophila, and mouse. Nematodes grown on media containing curcumin showed a significantly increased lifespan by reducing the production of reactive oxygen species.
Genes osr-1, sek-1, mek-1, skn-1, unc-43, sir-2.1, and age-1 are required for curcumin-mediated lifespan extension. The lifespan extension of Drosophila by curcumin supplementation was associated with increased superoxide dismutase (SOD) activity, and decreased lipofuscin and malondialdehyde levels. Curcumin up-regulated expression of SOD genes and down-regulated expression of several age-related genes, such as
dInR, ATTD, Def, learn more CecB, and DptB. In addition, THC extended lifespan in Drosophila and inhibited the oxidative stress response by regulating FOXO and Sir2. Mice fed diets containing THC starting at the age of 13 months had significantly increased mean lifespan. In summary, the positive effects of curcumin on lifespan extension likely arise from beneficial regulation of common oxidative stress responses and age-related genes. Understanding the molecular mechanism(s) of curcumin action has provided base knowledge and rationale for future human clinical trials, and for nutritional intervention in aging and age-associated disorders in humans. (c) 2013 BioFactors, 39(1):133140, 2013″
“Sixteen strains of luminescent bacteria of Vibrio and Photobacterium genera were isolated from water of the Azov and Black seas. Two strains prospective for biotesting were genetically identified as Vibrio fisheri V-9579 and Vibrio fisheri
V-9580 according to Russian Industrial Microorganism Collection (VKMP) classification and accepted for depositing. The isolated luminescent strains exhibited high individual sensitivity to oil derived products, heavy metal salts, sodium Ricolinostat manufacturer dodecyl sulfate (SDS) and phenol (up to the maximum concentration limit for fishery impoundments). According to EC(50), they are ten times more sensitive to heavy metal salts and potassium dichromate and 2-6 times more sensitive to SDS and phenol compared to P. phosphoreum (Cohn) Ford and Escherichia coli C600 (pPLS-5) strains. Using Vibrio fisheri VKMP V-9579 and Vibrio fisheri VKMP V-9580 as biosensors, we have shown their high sensitivity and efficacy to marine ecosystem toxicity assessment.”
“Curcumin, an active constituent of the spice turmeric, is well known for its chemopreventive properties and is found to be beneficial in treating various disorders including skin diseases. Curcumin protects skin by quenching free radicals and reducing inflammation through the inhibition of nuclear factor-kappa B.