In all 96 patients who underwent platinum-sensitive clinical recurrent, 48 (50.0%) patients were CA-125 SN-38 datasheet indicated asymptomatic relapse. Table 1 Patient characteristics of the study population Characteristic Percentage (%)/Median (range) Age (years) 61.6 (26–82) Baseline CA-125 level (U/mL) 582 (5–24260) Nadir CA-125 level (U/mL) 10 (3–35) Histology Serous 67 (69.8) Endometrioid
10 (10.4) Clear cell 8 (8.3) Mucinous 4 (4.2) Transitional 3 (3.1) Undifferentiated 3 (3.1) Malignant mixed müllerian tumor 1 (1.0) Grade Low 13 (13.5) High 83 (86.5) Surgical residual <1 cm 62 (64.6) 1–2 cm 3 (3.1) >2 cm 17 (17.7) Unknown eFT-508 14 (14.6) FIGO stage I 9 (9.4) II 8 (8.3) III 63 (65.6) IV 14 (14.6) Unknown 2 (2.1) Neo-adjuvant chemotherapy 68 (70.6) Paclitaxel-based 82 (85.4) FIGO the International Federation of Gynecology and Obstetrics. Survive related factors in platinum-sensitive recurrent ovarian cancer Univariate Cox proportional hazards model revealed that FIGO stage, pathological grade, outcome of CRS, nadir CA-125 level, ascities and PFS were associate with OS and TTP in all patients (Table 2). Multivariate analysis revealed that grade, nadir CA-125 level, optimal secondary CRS, ascities and PFS were independent OS and TTP predictors in platinum-sensitive recurrent EOC (Table 3). Table 2 Univariate analysis of survival-related characteristics in platinum-sensitive recurrent ovarian cancer Variable TTP (OR 95% CI)
OS (OR 95% CI) FIGO stage I 1.00(reference) 1.00(reference) II 1.25(0.57–4.31) 1.44(0.66–4.45) Akt activator III 3.09(1.53–8.36) 3.71(2.34–8.95) IV 4.64(2.85–12.26) 4.96(2.51–11.14) Grade Low 1.00(reference) 1.00(reference) High 5.22(2.14–12.76) 4.02(1.95–10.33) Ascites No 1.00(reference) 1.00(reference) Yes 1.78(1.44–2.38) 1.94(1.48–2.27) Optimal initial CRS Yes 1.00(reference) AZD9291 molecular weight 1.00(reference) No 6.07(2.50–15.91) 6.84(3.32–13.86) Optimal secondary CRS Yes 1.00(reference)
1.00(reference) No 5.28(1.86–16.93) 9.30(4.29–19.51) Neo-chemotherapy Yes 1.00(reference) 1.00(reference) No 1.19(1.04–1.57) 1.45(0.79–2.75) Paclitaxel-based chemotherapy Yes 1.00(reference) 1.00(reference) No 1.02(0.85–1.39) 1.35(0.83–2.01) PFS 1.02(1.00–1.18) 1.13(1.07–1.30) Nadir CA-125 1.02(1.00–1.03) 1.03(1.00–1.06) CRS cytoreduction surgery; OS overall survival; TTP time to progression; PFS progression-free survival. Table 3 Multivariate analysis of survival-related characteristics in platinum-sensitive recurrent ovarian cancer Variable TTP (OR 95% CI) OS (OR 95% CI) Grade Low 1.00(reference) 1.00(reference) High 3.74(2.01–10.35) 3.83(1.69–9.47) Ascites No 1.00(reference) 1.00(reference) Yes 1.62(1.37–2.51) 1.76(1.43–2.36) Optimal secondary CRS No 1.00(reference) 1.00(reference) Yes 6.27(3.84–14.28) 8.21(2.37–28.60) PFS 1.02(1.00–1.14) 1.10(1.04–1.36) Nadir CA-125 1.02(1.00–1.02) 1.03(1.00–1.04) The OS and TTP durations of ovarian cancer patients who underwent optimal secondary were longer than those who did not undergo (p = 0.02 and p = 0.