The whole-day concomitants of cocaine use were often distinct from the acute predecessors of use seen in prior analyses from
the same sample. Several measures of negative mood increased during abstinence.
Weeks of cocaine use and abstinence learn more in outpatients are associated with distinct patterns of mood and behavior; the detailed hourly data reported here should help inform treatment interventions aimed at changing daily activities. The findings also argue against the contention that cocaine abstinence symptoms decrease monotonically from the day of cessation.”
“Investigations of local field potentials of the subthalamic nucleus of patients with Parkinson’s disease have provided evidence for pathologically exaggerated oscillatory beta-band
activity (13-30 Hz) which is amenable to physiological modulation by, e.g., voluntary movement. Previous functional magnetic resonance imaging studies in healthy controls have provided evidence for an increase of subthalamic nucleus blood-oxygenation-level-dependant signal in incremental force generation tasks. However, the modulation of neuronal activity by force generation and its relationship to peripheral feedback remain to be elucidated. We hypothesised that beta-band activity in the subthalamic nucleus is modulated by incremental force generation. Subthalamic nucleus local field potentials were recorded intraoperatively Mocetinostat cost in 13 patients with Parkinson’s disease (37 recording sites) during rest and
five incremental isometric force generation conditions of the arm with applied loads of 0-400 g (in 100-g increments). Repeated measures analysis of variance (ANOVA) revealed a modulation of local field potential (LFP) power in the upper beta- band (in 24-30 Hz; F-(3.042) = 4.693, p = 0.036) and the gamma-band (in 70-76 Hz; F-(4) = 4.116, p = 0.036). Granger-causality was computed with the squared partial directed coherence and showed no significant modulation during incremental isometric force generation. Our findings indicate that the upper beta- and gamma-band power of subthalamic nucleus local field potentials EPZ-6438 mw are modulated by the physiological task of force generation in patients with Parkinson’s disease. This modulation seems to be not an effect of a modulation of peripheral feedback. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.”
“Only a small percentage of individuals seeking treatment for their marijuana use achieves sustained abstinence, suggesting more treatment options are needed.
We investigated the effects of baclofen (study 1) and mirtazapine (study 2) in a human laboratory model of marijuana intoxication, withdrawal, and relapse.
In study 1, daily marijuana smokers (n = 10), averaging 9.4 (+/- 3.9) marijuana cigarettes/day, were maintained on placebo and each baclofen dose (60, 90 mg/day) for 16 days.