They found that: (a) in the presence of the stump pain, a real circulation disturbance was highlighted by a distinctly lower temperature in the stump head region in comparison with the reference group; (b) an asymmetrical temperature rise was shown in localized areas corresponding to a pressure point, an infection, or a locally painful spot; (c) phantom pain was mostly related to thermal maps presenting a patchy distribution of cooler areas directly around regions with relatively higher temperatures. A temperature decrease from the proximal part to the stump head was observed in all cases.Wearable technologies can be applied to complement wide temperature maps with focused information on humidity inside the prosthesis during walking, integrated with temperature for a better assessment of the stump condition [1,2]. To the authors’ knowledge, no literature is available on this regard.Starting from these evidences and thanks to new miniaturized sensors, this study aimed at exploiting camera-based infrared thermography integrated with the ambulatory wearable monitoring of temperature (T) and relative humidity (RH) inside the prosthesis, for the assessment of the stump and of its interface with the liner. In particular, the system used for the assessment (hardware, software and measurement protocol), was expected: (1) to support in the analysis of temperature and humidity of the residual limb over time, e.g., before and after walking trials; and (2) to allow for the differential comparison of these parameters between measurement sessions. The goals of the present research were: (1) to develop and validate a wearable system measuring T and RH; (2) to propose an integrated clinical protocol based on infrared thermography and wearable sensors; and (3) to evaluate the in-vivo feasibility and relevance of this integrated protocol. Point 1 is addressed in Section 2, while reference 2 points 2 and 3 are covered in Section 3. A general discussion and conclusions are reported in Sections 4 and 5, respectively.2.?Wearable System��Development and Validation2.1. Materials and MethodsTo collect temperature and humidity data, the SHT21S sensor produced by Sensirion (Staefa, Switzerland) was chosen due to its limited size (3 �� 3 �� 1.1 mm), resolution (0.04% RH and 0.01 ��C) and expected accuracy tolerance (��2% RH, ��0.3 ��C)��Table 1 [23]. Sensors were mounted on a 1 cm diameter miniboard. A datalogger was also implemented to record data from at most 4 sensors, concurrently. It was based on the Seeeduino Stalker board (Seeedstudio, Shenzhen, China) and incorporated four USB ports for sensor connection. Sensors were connected to the USB ports through flat 4-wire cables. The datalogger embedded a 2 Gb micro-SD memory card for data storage. The data logger was programmed to store one temperature and one humidity datapoint every 2 s.