The surgeons in this study completely extroflexed the umbilicus www.selleckchem.com/products/Gefitinib.html and a skin incision was made longitudinally for about 1,5 to 2cm. Two types of trocars were used in the SPAAG and that were currently manufactured for this purpose: the TriPort (Advanced Surgical Concepts, Wicklow, Ireland) and the SILS Port (Covidien, Inc., Norwalk, CT, USA). For the patients included in the LAG, standard trocars were used. All trocars were placed under direct vision. Pneumoperitoneum was maintained at 14mmHg with carbon dioxide (CO2). The abdominal cavity was explored with a 10mm 30�� standard scope in both groups. The patients were then put in a Trendelenburg position and rotated to the left. In some patients in the SPAAG, reticulating instruments were used to create the necessary operative angle, according to technical difficulties (Reticulating Endo Mini-Shears; Autosuture and Reticulating Endograsp, 5mm; Autosuture).

The appendicular artery was first exposed, and then clipped if necessary with a standard 5mm clip applier or cauterized by bipolar grasper. Two endoloops were used at the stump of the appendix and then divided. Then, in both groups, a 5mm 30�� standard scope was used in order to extract the specimen. Careful control of homeostasis was then achieved, and drainage was left in place according to surgeon’s personal criteria. The fascial incisions were closed with an absorbable suture, and the umbilicus was restored with absorbable cutaneous stitches to its anatomic position. The rest of skin incisions were closed with absorbable cutaneous stitches.

Intraoperative complications such as bleeding, drain placement, surgical times (trocar(s) Entinostat placement, and surgical dissection and closure) were calculated. The uniformity of anaesthetic technique could not be established because of the different teams involved in each case. Postoperative complications and time for discharge have also been analysed. Pain referred by patients after 12 hours was measured with VAS [8]. All patients received paracetamol 1g/8h i.v. as a standard analgesic treatment. During the followup in the outpatient clinic, other data such as hernia or other complications were evaluated. The patients in the outpatient clinic, at one month after surgery, answered two questions: ��How much satisfied with the surgery are you? (0�C10)�� and ��How satisfied are you with the cosmetic result of the surgery? (1�C10).�� These short questions pretended to know about the degree of satisfaction and the satisfaction with the cosmetic result. 2.2.