This explains why enhanced relaxation and sense of well being occurs during use of caffeine in stressful event [17]. Energy drinks usage has now become Carfilzomib Phase 2 wide spread among college students, particularly who want to meet both cognitive and physical performance demand [4,14]. High intake of energy drinks, particularly brand that contain high quantity of caffeine can result in the slow downing the rate at which nutrient is absorbed into blood stream; it also slow downs the rate of fluid absorption or dehydration during an exercise. Excessive caffeine Inhibitors,Modulators,Libraries provides a blast of energy enabling the person to feel good initially but when energy is burn up in 30�C40 minutes, there is a sugar crash [4]. Findings of our study is also consistent with past study which shows that person who consumed energy drinks reported less sleepiness and increased alertness [18].

Approximately 15.3% person claim dehydrating effect of energy drinks on their body which was consistent with Inhibitors,Modulators,Libraries past studies [4,19]. It may be due to the fact that there were serious consequences when a person substitute energy drinks for water during strenuous physical activity, this is because caffeine act as diuretic agent and it removes extra fluid from the body therefore if a person consume it while sweating, and it will result in severe dehydration [4]. In our setup prevalence of insomnia due to energy drinks was around 17% which was much less than a study occur in Thailand [20]. Most subject who reported recreational use experience symptoms such as palpitation, tremors, seizures, inability to focus, accelerated heart rate and gastrointestinal upset, the same as reported in past studies [21-23].

Elevation of blood pressure and heart rate was may be due to the pressor effect of caffeine which cause peripheral vasoconstriction rather than enhancement of cardiac output [24]. Energy drinks target market is different than in some of the other beverage industries. Inhibitors,Modulators,Libraries When they were first being sold in United States, athletes were primary consumers. But now marketing has been expanded beyond that of simply athletes. Although everyone is susceptible to the fatigue of the super-charged, over-worked lifestyle but young people are especially vulnerable to persistent exhaustion and insufficient energy. This group of people, more specifically male teenagers and people in their 20s and 30s, are also most Inhibitors,Modulators,Libraries likely to believe in the veracity of the energy drinks�� claims.

As a Inhibitors,Modulators,Libraries result, the majority of energy drinks are developed for and advertised to this younger generation. Same results were found in our study as mostly users of energy drinks start using them by watching its advertisement on television. Symptoms of caffeine withdrawal including fatigue, insomnia, muscle aches, irritability, and depression begin in 12�C24 hours after the last dose of Energy drinks; our findings were consistent with past Entinostat study [12].