We thank Philip van der Wees for his contribution to the development Oligomycin A solubility of the intervention. The publication of this paper was funded by the Netherlands Organisation for Scientific Research (NWO).
Energy drinks are caffeinated beverages first appeared in Europe and Asia in the 1960s but did not become popular until the most widely known brand, Red Bull, was released in Austria in 1987; hitting the US market in 1997. By 2006, there were over 500 brands of energy drinks around the world, with sales exceeding $500 million per annum in the US [1]. An energy drink is a type of beverage containing stimulant drugs, chiefly caffeine, which is marketed as mental and physical stimulator. Coffee, tea and other naturally caffeinated beverages are usually not considered as energy drinks.

Soft drinks such as cola, may contain caffeine, but did not include in energy drinks [2]. Prevalence of energy drinks use among adolescent and young adults to be 30-50% [3]. Studies have also demonstrated its high consumption in young athletics [4]. Energy drinks generally contain methylxanthines (including caffeine), taurine, glucuronolactone, B Vitamins, and herbs. Other commonly used ingredients are carbonated water, guarana, yerba mate, a?a��, and taurine. Probably they are responsible for the possible medical side effects of energy drinks [5]. Energy drinks are consumed by younger population for different reasons particularly for studying, partying, driving, for energy boost and wakefulness [6]. There is a positive association between energy drink consumption and improved psychomotor and mental performance because of the interaction of its various constituents [7].

In conjunction with its positive effects, there are reviews on the negative effects of energy drinks as well [8]. According to a study, energy drinks have shown its great effect on cardiovascular system in terms of modulating the heart rates and blood pressure [9]. It was also proven that its consumers have experienced neuropsychosis as caffeine induces psychosis in those without a previously diagnosed psychotic disorder [10]. Frequency of energy drink consumption was positively associated with ��problem behaviors�� exhibited Carfilzomib as sexually risky behaviors, marijuana use, fighting, and failure to use seat belts [11]. It was also consider that genetic factors and pharmacological intolerance responsible for individual��s vulnerability to caffeine related disorders including caffeine intoxication, dependence, and withdrawal [12]. It also has erosion characteristics of dental enamel [13]. Objectives In Pakistan very little concentration has given on energy drinks and there is not much data available regarding the awareness, prevalence and side effects of consuming energy drinks.