Time between first RF application and AF termination, and RF duration until AF termination, was recorded. CFAE area/total LA surface was also
measured on CARTO maps (Biosense Webster, Diamond Bar, CA, USA). These measures served to evaluate ablation difficulty, and were correlated with CMR images by double-blinded analysis.
Results: Ablation restored sinus rhythm in 20 of 22 patients (91%), with a time to terminate AF of 140 +/- 91 minutes. There was a significant correlation between the global averaged DE-CMR fibrosis grade and the electrophysiological substrate indexes such as “”time to terminate AF”" (Rho = 0.70, P = 0.0003), “”RF duration until AF termination”" (Rho = 0.65, P = 0.001), and a trend toward correlation with “”CFAE area/LA surface”" (Rho = 0.47, MEK inhibitor P = 0.03).
Conclusions: LA DE-CMR can predict increased difficulty of CFAE ablation in AF. This tool may be beneficial in both selection of patients and ablation strategy. (PACE 2011; 34:1267-1277)”
“Purpose: The space environment contains two major biologically significant influences; space radiations and microgravity. The 53 kDa tumour suppressor protein (p53) plays a role as a guardian of the genome through
the activity of p53-centered signal transduction pathways. The aim of this study was to clarify the biological effects of space radiations, microgravity, and the space environment on the gene expression of p53-regulated genes.
Materials and methods: Space experiments were performed with two human cultured lymphoblastoid cell lines; one line (TSCE5) bears DMH1 molecular weight a wild-type p53 gene status, and another line (WTK1) bears a mutated p53 gene status. Under one gravity or microgravity conditions, the cells were grown in the cell biology experimental facility (CBEF) of the International Space Station for 8 days without experiencing stress during launching and landing because the cells were frozen during
these periods. Ground Ralimetinib control samples also were cultured for 8 days in the CBEF on the ground during the spaceflight. Gene expression was analysed using an Agilent Technologies 44 k whole human genome microarray DNA chip.
Results: p53-dependent up-regulated gene expression was observed for 111, 95, and 328 genes and p53-dependent down-regulated gene expression was found for 177, 16, and 282 genes after exposure to space radiations, to microgravity, and to both, respectively.
Conclusions: The data provide the p53-dependent regulated genes by exposure to radiations and/or microgravity during spaceflight. Our expression data revealed genes that might help to advance the basic space radiation biology.”
“In this paper we investigate the Jahn-Teller distortion and magnetic property in parent and doped anisotropic triangular compound NaxMnO2. We first determine the Jahn-Teller distortion modes of the MnO6 octahedra by minimizing the potential energy.