Well-designed longitudinal clinical trials are needed to confirm the findings of the present investigation in
terms of quality of life after surgical treatment of intra-articular distal radial fractures.”
“A sensitive and simple liquid chromatography- mass spectrometry (LC-MS) method was developed and validated for determination of four cytochrome P450 probe drugs (phenacetin (CYP1A2), tolbutamide (CYP2C9), bupropion (CYP2B6) and omeprazole (CYP2C19) in rat plasma. Four cytochrome P450 probe drugs extracted from plasma samples by protein precipitation with acetonitrile and separation were carried out on Agilent Zorbax SB-C18 column (2.1 mm x 150 mm, 5 mu m) at 30 degrees C, acetonitrile -0.1 % formic acid in water used as mobile phase with gradient elution. Electrospray ionization (ESI) source was applied and operated in positive
ion PF-562271 cost mode, and selective ion monitoring (SIM) mode was used to quantify cytochrome Acalabrutinib P450 probe drugs. The method showed excellent intra-assay and inter-assay precision (relative standard deviation (RSD) and bias <15 %) for quality control (QC) samples spiked at a concentration of 10, 400, and 1600 ng/mL and the r(2) > 0.99 over the range investigated (5-2000 ng/mL). Lower limits of quantification (LLOQs) were estimated to be 5 ng/mL. The method was successfully applied to determinate cytochrome P450 probe drugs in a pharmacokinetic study.”
“Background: A major cause of the limited longevity of total ankle replacements is premature polyethylene component wear, which can be induced by high joint contact pressures. We implemented a computational model to parametrically explore the hypothesis that intercomponent positioning deviating from the manufacturer’s recommendations can result in pressure distributions that may predispose to wear of the polyethylene insert. We also investigated the hypothesis that a modern mobile-bearing design may be able to better compensate for imposed misalignments compared with an early two-component design.
Methods:
Two finite element models of total ankle replacement prostheses were find more built to quantify peak and average contact pressures on the polyethylene insert surfaces. Models were validated by biomechanical testing of the two implant designs with use of pressure-sensitive film. The validated models were configured to replicate three potential misalignments with the most clinical relevance: version of the tibial component, version of the talar component, and relative component rotation of the two-component design. The misalignments were simulated with use of the computer model with physiologically relevant boundary loads.
Results: With use of the manufacturer’s guidelines for positioning of the two-component design, the predicted average joint contact pressures exceeded the yield stress of polyethylene (18 to 20 MPa).