The heart sounds showed no abnormalities, except for a mild systolic (grade II/VI) murmur. The remaining physical examination was normal. Laboratory results showed a severe metabolic acidosis with a HCO3- of 4.2 mmol/L and pH of 6.69. The serum osmolality was 379 mosmol/kg, Na+ 146 mmol/L,
K+ 7.7 mmol/L, Urea 5.8 mmol/L, Glucose 4.6 mmol/L, Cl- 111 mmol/L and Lactate 11.2 mmol/L. Immediately after arrival the patient was intubated and central venous access was obtained. Because of the suspicious circumstances, the severity of disease, the depth of acidosis and the osmol, anion an bicarbonate gap of respectively 73 mosmol/kg, Inhibitors,research,lifescience,medical 39 mmol/L and 6, methanol or ethylene glycol intoxication was suspected, even though the patient carried Inhibitors,research,lifescience,medical a document with a negative toxicology screen, as proof of a life without drugs, ethanol and even methanol, that was signed for his contractor only a few weeks ago (Figure (Figure11). Figure 1 Official proof of negative alcohol screening. Anion gap ([Na]+ [K]) – ([CL]+ [HCO3]) = (146+7.7) – (111+4.2) = 39 mmol/L Osmol gap Serum osmol – (1.86 (Na+K) + glucose + urea + 10) = 379-306
= 73 mOsm/kg [10,11]. Delta gap or Bicarbonate gap (AG-Normal AG) – (Normal bicarbonate- [HCO3]) = (38-12) – (24-4) = 6 indicating an almost pure anion gap acidosis . The patient was transferred to the ICU where CVVH-DF was Inhibitors,research,lifescience,medical promptly initiated combined with a continuous infusion of 22 grams ethanol per hour over a central venous catheter, after an i.v. loading dose of 62 grams. The hypotension was successfully treated with volume suppletion and norepinefrine with a maximum dose in the first hours of 1.57 microgram/kg/min. Folate and thiamine were also administered. Following these measures Inhibitors,research,lifescience,medical the hemodynamic condition of the patient BI 6727 chemical structure improved markedly. The pH and lactate levels normalized, Inhibitors,research,lifescience,medical as did the methanol concentration (Figure (Figure22). Figure 2 pH, methanol and ethanol in g/L versus time. During the CVVH-DF we were able to maintain a stable serum ethanol concentration between 1-1.5 g/L. Although the hemodynamic parameters improved, the
CYTH4 patient remained unresponsive and unconscious. Because of the initial high level of methanol and the severity of the acidosis, severe neurological damage was to be expected. Neurological examination showed signs of severe neurological damage like apnea, a negative vestibular caloric test and absence of the corneal and oculocephalic reflex. Our patient developed also diabetes insipidus at that time. A CT scan was made to visualize the nature and severity of the damage. This scan showed massive edema with diminishing grey- and white matter differentiation both supra and infra tentorial. The third and fourth ventricle as well as the basal cisterns were not identifiable anymore (Figure (Figure33). Figure 3 Severe cerebral edema with compression of the ventricles.